Prevalence of anxiety, depression and post-traumatic stress disorder symptoms and resilience in adolescents during the COVID-19 pandemic in a post-armed conflict area in Colombia (preprint)

The impact of COVID-19 pandemic on mental health of adolescents are emerging and require particular attention in settings where challenges like armed conflict, poverty and internal displacement have previously affected their mental wellbeing. This study aimed to determine the prevalence of mental health problems and symptoms of anxiety and depression, probable post-traumatic stress disorder, and resilience capacity in adolescents in a post-armed conflict area in Colombia during the COVID-19 pandemic. A cross-sectional study was conducted with 657 school attending adolescents aged 12 to 18 years old. Mental health information was obtained through screening scales for anxiety (GAD-7), depression (PHQ-8), probable post-traumatic stress disorder (PCL-5) and resilience capacity (CD-RISC-25). The prevalence observed for moderate to severe depression symptoms was 30.0% (CI95%=26.5–33.7) and for moderate to severe anxiety symptoms was 18.9% (CI95%=16.0-22.1). A prevalence of probable post-traumatic stress disorder (PTSD) of 22.3% (CI95%=18.1–27.2) was found. The CD-RISC-25 results for resilience had a median score of 54 [IQR:30]. Our results are in line with emerging evidence that suggests multiple domains of adolescents’ mental wellbeing were negatively impacted by the pandemic, and agree with other studies of regions affected by the armed conflict that show an increase in the prevalence of mental health disorders in young populations. In contrast, our data show lower resilience than other studies of adolescents. These findings call for multidisciplinary actions necessary to respond effectively to the impact of the pandemic on the mental health of adolescents, as well as to guarantee a successful educational recovery, being schools key places in which prompt intervention might reduce the burden of mental distress in adolescents.

Role of the Arts in the Life and Mental Health of Young People That Participate in Artistic Groups in Colombia: a Qualitative Study (preprint)

Background: Young adults and adolescents are in stage where their mental health is more vulnerable. In Latin América, there are factors that predispose young people towards an increased risk of suffering from mental illness. However more than half of the young people who manifest symptoms of depression and anxiety are able to overcome these episodes approximately one year after the onset of symptoms. This is related to the concept of resilience. Methods: : The main objective of the study was to characterize the role of the arts in relation to mental health in young people involved in artistic organizations in Bogota. Six artistic workshops and focus groups were conducted, with 38 participants from two arts organizations in Bogota. The type of artistic workshop varied depending on the type of art taught in each institution. The focus group discussions were recorded, transcribed, coded and analyzed using an inductive analysis methodology. Results: : There were five themes that emerged in explaining the role of the arts in relation to the mental health of young people. These themes included i) the management and expression of emotions, ii) the transformation of emotions, iii) the distracting quality of the arts, iv) the arts as a social facilitator and v) the arts as part of the identity and lifestyle of young people. Conclusions: : For young people who participate in artistic activities, the arts are a tool for managing emotions perceived as negative, such as stress, anxiety, depression and sadness. Their perception of the arts as a tool for mental health was viewed differently depending on whether it is perceived as a professional vocation versus a hobby. These findings are relevant within the context of the COVID-19 pandemic, taking into account that the participants were exposed to various mental health risk factors, such as an extended obligatory quarantine and social distancing.

Effectiveness of Rosuvastatin plus Colchicine, Emtricitabine/Tenofovir and a combination of them in Hospitalized Patients with SARS Covid-19 (preprint)

ABSTRACT BACKGROUND The effectiveness of rosuvastatin plus colchicine, emtricitabine/tenofovir, and of their combined use in hospitalized patients with coronavirus disease 2019 (Covid-19) pneumonia is unclear. METHODS In each hospital, hospitalized adults with Covid-19 pneumonia, were randomly assigned, in a 1:1 ratio, to receive: a) standard of care; or b) emtricitabine/tenofovir; or c) colchicine + rosuvastatin; or d) emtricitabine/tenofovir + colchicine + rosuvastatin. The primary outcome was all-cause mortality within the first 28 days after randomization. Severe adverse events (SAE) were those with a high probability of being treatment-related. RESULTS 633 patients were randomized in 6 hospitals in Bogota, Colombia. Overall, 98% of the patients received glucocorticoids during hospitalization. The cumulative incidence of death through day 28 was 10.7% in the emtricitabine/tenofovir + colchicine + rosuvastatin arm, 14.4% in the colchicine + rosuvastatin arm, 13.8% in the emtricitabine/tenofovir arm, and 17.4% in the standard of care arm, with adjusted risk differences (aRD) against the standard treatment of -0.07 (95% confidence interval [CI], -0.17 to 0.04), aRD -0.03 (95%CI: -0.11 to 0.05) and aRD: -0.05 (95%CI: -0.15 to 0.05), respectively. Need for invasive mechanical ventilation was lower in the emtricitabine/tenofovir + colchicine + rosuvastatin arm compared to the standard treatment arm, aRD: -0.06 (95%CI: -0.11 to -0,01), but no differences were found between the other comparisons. SAE occurred in 3 patients distributed in the 3 treatment arms. CONCLUSIONS Among patients hospitalized with moderate and severe SARS Covid-19, the use of the emtricitabine/tenofovir + colchicine + rosuvastatin combination emerges as a treatment alternative. ClinicalTrials.gov number: NCT04359095